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RNF217 was identified as a novel E3 ubiquitin ligase and was shown to play a role in mediating the degradation of FPN [30]

Miura M, Ohkubo T

The underlying mechanism of how GSH modulate the complex crosstalk between ferroptosis and autophagy remains unclear

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It plays a pivotal role in glucose metabolism and appetite regulation through multiple mechanisms: Enhances insulin secretion: GLP-1 stimulates pancreatic -cells to release insulin in a glucose-dependent manner Suppresses glucagon: Reduces hepatic glucose production Delays gastric emptying: Creates prolonged satiety Central nervous system effects: Acts on appetite centers in the brain to reduce hunger and food intake Protects pancreatic -cells: Promotes cell proliferation and inhibits apoptosis GLP-1 Receptor Agonists in Clinical Practice GLP-1 receptor agonists (GLP-1 RAs) are medications designed to mimic the action of endogenous GLP-1 but with enhanced pharmacokinetic properties

USA 113 , E2564E2569 (2016)