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3 The onset and development of cuproptosis 3.1 Cuproptosis Recently, a novel form of copper-dependent cell death, reliant on mitochondrial respiration, has been identified and termed cuproptosis (Tsvetkov et al., 2022)

Bilirubin Heme oxygenase-1 (HO-1) is the enzyme that generates carbon monoxide, iron, and biliverdin using the heme fraction as a substrate [39], and biliverdin reductase that reduces biliverdin to bilirubin being this molecule the ending product of the heme degradation

Structure and function of the xenobiotic substrate binding site of a glutathione S-transferase as revealed by X-ray crystallographic analysis of product complexes with the diastereomers of 9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene

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10.1038/nature10957 Nature Summary Keywords immunity, microbial interventions, psoriasis, gut microbiota, skin microbiota Citation Chen L, Li J, Zhu W, Kuang Y, Liu T, Zhang W, Chen X and Peng C (2020) Skin and Gut Microbiome in Psoriasis: Gaining Insight Into the Pathophysiology of It and Finding Novel Therapeutic Strategies