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These findings are based on animal models and in vitro research and have not been conclusively demonstrated in human clinical studies

The good results of the antioxidant treatment described above also prove that the doses used were adequate and the concentrations of the substances employed did not exceed the threshold beyond which they might have instead interacted negatively with the mechanisms of redox regulation of the tissues (see antioxidant paradox) [180,181]

If those appear, the reaction is something more serious than the copper uglies and you should stop the product immediately and consult a dermatologist

Expected timeline: Visible improvement in two to three months

The remaining -defensins ( DEFL1 , DEFL2 , DEFL3 , DEFB103 ) and the -defensin ( DEFA5L ) were analyzed by Bruhn et al