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Upon receptor activation, intracellular signalling cascades involving phospholipase C, inositol triphosphate, and calcium mobilisation are initiated, leading to pulsatile release of growth hormone independent of hypothalamic growth hormone releasing hormone (GHRH) stimulation

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Glycyl-L-histidyl-L-lysinecopper (GHK-Cu), an endogenous tripeptidemetal complex, has attracted increasing interest due to its multifaceted biological roles in tissue repair, anti-inflammatory regulation, extracellular matrix remodeling, and redox homeostasis