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In adults, cytochrome P450 enzymes metabolize 45% of the paracetamol to NAPQI, and this percentage increases when glucuronidation and sulphation are saturated
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In vitro models indicated that combining TG2 inhibitors with amikacin enhanced their antimicrobial activity in M.tb -infected macrophages and the granuloma-like structure ex vivo model [24]
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A major limitation was the inability to determine why patients were not referred to MMGS
