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Thus, further studies on a diverse set of in silico, in vitro, and in vivo animal models are required and standardization of the pathognomic behavioral assay in order to establish pathogenic hotspot of disease and to evaluate the novel dietary/metabolic therapy that can provide insight into the neurobiology of ASD is warranted

484 Since the severe toxicity of high-dose IL-2 and IFN- leads to the intolerance of patients to treatment and restrains the therapeutic efficacy in a large population, the combination of chemotherapies, targeted therapies or other immunotherapies with low-dose IL-2 or IFN- has been employed in some investigations to avoid the side effects brought by single high-dose cytokines therapy, which can meanwhile achieve better treatment response

Timothy Piatkowski, a senior research fellow at the University of Queensland who researches the harms of some peptides, said the TGA's safety alert was a "step forward"

Associating HP--CD with gentamicin showed a decrease in renal toxicity which allows an effective treatment without compromising the renal function

Deficient vitamin B12 levels may also lead to damage in the tiny blood vessels in the ear

Clin Chem 46 : 258264
