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J.ZhangH.KatsyubaE.AuwerxJ

Synthesis of carnitine occurs in the kidney, liver and brain, and it is transported to other tissues in the circulation before it is taken up by tissues by carnitine transporters at the plasma membrane that are tissue-specific

Although these methods have proven clinical efficacy, they fail to directly target the central pathophysiologic mechanisms at play in heart failure

doi: 10.1212/01.wnl.0000052998.58526.a9

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Comparative study to evaluate the effect of l-carnitine plus glimepiride versus glimepiride alone on insulin resistance in type 2 diabetic patients