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community and clinical sources describe dermatological monitoring for these changes, especially with long-term use Injection site darkening localized hyperpigmentation Mood changes irritability reported by some during loading Managing nausea: community sources commonly describe beginning at 100-250 mcg, injecting before bed on an empty stomach, using anti-nausea medication (ondansetron) when needed, and escalating the dose gradually
Studies using a range of magnetic resonance imaging (MRI) techniques including diffusion kurtosis/tensor (DKI/DTI) (2), magnetization transfer (MT) (3) and magnetic resonance spectroscopy (MRS) (4) have shown that myelinated tracts progressively degrade at during normal aging
