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The mechanism of ATRAs inductive effect on GS expression required ERK1/2 signaling but the mechanism is not clear, as ATRA treatment did not influence the expression of Nrf2 or NFB and it had no effect on the GS promoter activity [141]
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They also powerfully aid the liver in its detox duties by trapping toxins and escorting them out of the body

It interferes with reabsorption of sodium in the renal tubules

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