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In vitro study using human vascular endothelial cells further confirmed the increased mRNA and protein expressions of VEGFR2 but not VEGF-A by BPC 157

The increased apoptosis was related to the activation of p53 and p21, the decrease of the Bcl-2/Bax ratio, and the increase of caspase-3 and phosphorylated c-Jun N-terminal kinase (p-JNK) activity

375,376,377,378 Additionally, the use of small molecules that act as UHRF1 degraders, such as diosgenin and MK2206, has been explored for prostate cancer treatment, representing a novel therapeutic approach

Nutr Rev 1998;56(11):317333

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