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Simvastatin, a semisynthetic lipophilic HMG-CoA reductase inhibitor, has demonstrated anti-fibroid properties by inhibiting fibroid cell proliferation, decreasing the expression of proliferative markers such as Ki67, and promoting apoptosis of fibroid cells (in a dose-dependent manner) in in vitro studies [81,83]

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While H3K27me3-enriched Foxa1 gene was in greater amounts in sperm from subfertility bulls, the others were enriched in sperm from high-fertility bulls (168)

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doi: 10.3109/15622975.2011.559274