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As was noted for DNMT1 and PRMT3, sigmoidal dose-response curves and reliable estimates of IC 50 values could not be obtained since no significant inhibition was observed at the tested NNMT inhibitor concentrations

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2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society