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Abstract : Purpose : Glutathione depletion has been documented in several disease states, and exogenous administration has been hypothesized to have therapeutic potential for some conditions

The British Journal of Psychiatry (Review, meta-analysis)

216 The CS resulting from the significant release of IL-1 and TNF has the potential to induce myocardial suppression, vasodilation, tissue injury, and mortality through the upregulation of nitric oxide synthesis, myocardial cell contraction, facilitation of immune cell adhesion and activation, and initiation of exogenous coagulation pathways

[ref] Talk with your doctor or pharmacist if you are on prescription medications to see if there is any interaction with any new supplement before you start it

Medical service experts must be cautious when prescribing this medicine to persons on multiple medicines

Direct glutathione supplementation might be worth considering for those who don't respond adequately to NAC or who want to explore advanced liposomal formulations