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Defense Against Oxidative Stress NAD+ supports antioxidant systems by aiding enzymes like glutathione reductase to regenerate glutathione, a key antioxidant that protects cells from oxidative damage

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Efforts to enhance antioxidant properties through molecular modifications, using advanced technologies such as prodrug strategies, nanotechnology, polymer complexation, targeted delivery systems, or conversion into inhalable formulations, have yielded variable success

doi: 10.3389/fphar.2014.00260 Received 09 July 2014 Accepted 08 November 2014 Published 27 November 2014 Volume 5 - 2014 Edited by Alfonso Pompella, Universit di Pisa, Italy Reviewed by Salvatore Salomone, Catania University, Italy