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This study employed a comprehensive proteomic and metabolomic analysis to characterize adaptive cellular mechanisms of priority pathogensEscherichia coli, Klebsiella pneumoniae, Enterococcus faecium, and Staphylococcus aureusunder sub-inhibitory concentrations of antibiotics

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Finally we present strategies involving the application of ischemic preconditioning and pharmacological agents, eg -lactam antibiotics, amitriptyline, riluzole and N-acetylcysteine, which result in the significant protection of nervous tissues against ischemia.