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Lifestyle Interventions (First-Line) Dietary modification: Caloric restriction, specific dietary patterns (Mediterranean, low-carbohydrate, DASH)

Elahi D, McAloon-Dyke M, Fukagawa NK, Sclater AL, Wong GA, Shannon RP, Minaker KL, Miles JM, Rubenstein AH, Vandepol CJ

The body tightly regulates vitamin levels, and excess water-soluble vitamins like B12 are typically excreted in urine

but if used improperly (for example, if accidentally infused alone), it can cause serious complications like hemolysis

They are not aware of the need to ensure they have adequate levels of B12 and so far, the evidence suggests that people who are vegan are less likely to be overweight, and at less risk of type 2 diabetes and heart disease

High-dose niacin can cause liver injury