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222 Simultaneously, RNF43 and KRAS mutations show a synergistic effect in CRC progression

While its main function is to carry out cellular respiration, a process that converts nutrients from food into ATP, there are many other functions mitochondria perform, including metabolic signaling, calcium regulation, autophagy (cellular clean-up) and apoptosis (cell death), neurogenesis (growth of new nerve tissue) and neuronal plasticity (aka neuroplasticity- our brains ability to grow and adapt), as well as the synthesis of other molecules (especially those in the immune system)

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Furthermore, the chronic respiratory acidosis prompts renal compensation via the retention of bicarbonate to buffer the excess carbon dioxide

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241 This bidirectional exchange, where signaling shapes metabolism and metabolism rewires signaling, forms a robust circuit that endows CSCs with increased survival capacity and flexibility to evade therapy