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Whether Regucalcins gluconolactonase activity is essential for calcium homeostasis is unclear, since this role may be played through the inferred binding surface of Regucalcin-like proteins

The reaction was terminated by adding 5 l of 4x LDS sample buffer (Invitrogen) followed by denaturing the samples at 70C for 10 min

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Curley DE, Webb AE, Sheffler DJ, Haass-Koffler CL (2021) Corticotropin releasing factor binding protein as a novel target to restore brain homeostasis: lessons learned from alcohol use disorder research

NCR has been described to respond to glutamine and glutamate deficiencies through the activation of Gln3 or Gat1 respectively, while ammonium is considered a distinct signal for NCR that acts independently of the glutamine and glutamate levels [34]

134,135 Chronic tissue inflammation has a vital role in the etiology and immunopathogenesis of rheumatoid arthritis, with genetic and environmental factors contributing to a predilection to develop the disease