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Reactive oxygen species

Blood 124 , 25692574 (2014)

MDM2 was proven to ubiquitinate the IGF-1R and degraded it in a proteasome-dependent manner (Girnita et al, 2003), eventually leading to cell death

The second factor is the fact that the benefits of H 2 to the mitochondria include an increase in the mass of this organelle, the concentration of the superoxide radical within it, and an increased membrane potential [109]

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However, the phase III study of GM1 did not support the use of GM1 to prevent cumulative OIPN, although patients receiving GM1 were less disturbed by acute neuropathic symptoms (Wang et al., 2020)