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10.1016/j.jgg.2021.08.017 J Genet Genomics

Mice deficient in GPx1 exhibit an increased sensitivity to MPTP toxicity [166], while its overexpression protects against MPP + - and 6-OHDA-induced toxicity in vitro and in vivo [35, 157, 277, 312]

Small-molecule LDC7559 can also significantly reduce the formation of NETs by activating the glycolytic enzyme phosphofructokinase-1 liver type and suppressing the pentose phosphate pathway in neutrophils to inhibit ROS generation 37

Abstract Lung cancer patients face a dismal prognosis mainly due to the low efficacy of current available treatments