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Myth: "More is always better." Fact: High doses of magnesium can cause a laxative effect if taken all at once

A weaker heart might not be able to pump blood, which results in shortness of breath and edema

10.1038/s41582-020-00435-y 114 LevN.IckowiczD.MelamedE.OffenD

Abbreviations 8-OHDG: 8-hydroxy-deoxyguanosine BCL10: B-cell lymphoma/leukemia 10 CAT: Catalase CL: Corpus luteum CORT: Corticosterone COX2: Cyclo-oxygenase 2 Cu-Zn SOD: Copper-zinc SOD ERK1/2: Extracellular regulated kinase 1/2 ETC: Electron transport chain FSH: Follicle-stimulating hormone GCLC: Glutamate-cysteine ligase subunit catalysis GPx: Glutathione peroxidase GSR: Glutathione reductase HCG: Human chorionic gonadotropin HO-1: Heme oxygenase 1 IGFBP1: Insulin-like growth factor-binding protein 1 IKK: Inhibitor of nuclear factor kappa-B kinase IUGR: Intrauterine growth restriction JNK: Jun N-terminal kinase Keap1: Kelch-like ECH-associated protein 1 MAPK: Mitogen-activated protein kinase MCP-1: Monocyte chemoattractant protein-1 MDA: Malondialdehyde MIF: Migration inhibitory factor MnSoD: Manganese superoxide dismutase NAC: N-acetylcysteine NADP(H): Nicotinamide adenine dinucleotide phosphate NF-B: Nuclear factor-kappa B NQO1: NAD(P)H dehydrogenase (quinone 1) OS: Oxidative stress ox-LDL: Oxidized LDL PCOS: Polycystic ovary syndrome PGF 2 : Prostaglandin-F-2 PRL: Prolactin SO: Superoxide SOD: Superoxide dismutase TAS: Total antioxidant status TNF-: Tumor necrosis factor- uNK: Uterine natural killer VEGF: Vascular endothelial growth factor References Burton GJ, Jauniaux E

Regulatory agencies should establish guidelines for GPS-based pharmaceuticals, including specifications for purity, stability, and impurity limits (EFSA Panel on Additives and Products or Substances used in Animal Feed, 2023

Five studies enrolled participants with MDD, 16,17,19,20,25 and four focused on dysthymic disorder (DSM-IV criteria)