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Mechanistically, HSCs engage in bidirectional crosstalk with UM cells, leading to upregulation of inflammatory cytokines (e.g., interleukins) and transmembrane integrins in tumor cells, suggesting that inflammatory signaling pathways are central to LMUM progression [47]

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B., Flier, J

This approach signifies a progressive transition toward a rational matrix screening methodology that was previously based on empirical observations

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Tracey KJ, Wei H, Manogue KR, et al