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Description
We report a deficient activity of both PST isoforms (M and P) in platelets from individuals with ASD (35% and 78% of patients, respectively), confirmed in autoptic tissues (9 pineal gland samples from individuals with ASDan important source of serotonin)

489492, Mar
Acta Pharmacol Sin 44(5):10141028 Tschuck J, Theilacker L, Rothenaigner I, Wei SAI, Akdogan B, Lam VT, Mller C et al (2023) Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis

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There may also be bright spots at the macula
All these enzymes are either involved in the oxidation of fatty acids, D-amino acid catabolism and anabolism, glyoxylate/dicarboxylate metabolism, or in the production of spermidine, an autophagy-stimulating, life-prolonging substance