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Insufficient sampling frequency (e.g., 2060-minute intervals) fails to capture these rapid bursts, leading to a profound underestimation of pulse frequency and amischaracterization of the secretory profile

Despite the advances for crossing the HLA barrier in transplantation, the use of immunosuppressive drugs is necessary to achieve graft long-term outcomes, but it is accompanied by reduced immunity to infection and malignant diseases (122) ( Table 1 )

10.1093/jexbot/53.366.103 J

References (1) Francis GL, et al

These drugs were promising early on, but many were abandoned for either failing to show clear benefits or for allegedly causing severe side effects

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