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One of these is called necroptosis that represents a programmed form of necrosis 28,44

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Gastrointestinal symptoms often present years before motor symptoms in PD and evidence suggests gut microbes play a role in PD pathogenesis via the microbiota-gut-brain axis (52)

The main focus of MMDD in treating PF is to reduce inflammatory cytokines, inhibit pro-fibrotic factors and oxidative stress, promote differentiation and homing of bone marrow mesenchymal stem cells, and enhance cell autophagy activity