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The presence of a disulfide bridge, combined with the addition of tyrosine at the N-terminus, significantly enhances the peptides stability, making it orally active [8]

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However, the so-called heme-anemic proteins with an incomplete heme saturation naturally occur outside the circulatory system [150]

Although the current evidence is very promising, there are still some knowledge gaps that should be addressed to further clarify the exact mechanisms linking NNMT to obesity and T2D and to develop clinical drugs targeting NNMT

I had a consultation with the neurology dept at the NIH