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In hypogonadotropic hypogonadism, decreased levels of GnRH, FSH, and/or LH result in impaired testicular function, often leading to low energy and infertility in reproductive-aged men

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Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males

In the testicular environment, excessive ROS not only damages cell membranes, proteins and DNA, but also compromises the integrity of the seminiferous tubules, which is a natural niche for germ cell development 8

Glutathione plays an important role in the detoxification of reactive oxygen species (ROS) in the central nervous system, where it directly quenches radicals in nonenzymatic reactions and reduces peroxides generated by glutathione peroxidase