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[DOI] [PubMed] [Google Scholar] Bella DL, Hirschberger LL, Hosokawa Y, Stipanuk MH

This enhances apoptosis induction and can reverse multidrug resistance when used alone or in combination with chemotherapeutics ( Controlled and stimuli-responsive release: Smart NPs (pH/redox/enzyme responsive) enable site-specific drug release in the acidic/reductive tumor microenvironment, reducing systemic toxicity and improving intratumor drug concentrations ( Synergy & combination delivery: Hybrid lipid-polymer or liposome-silica platforms allow co-delivery (e.g., phytochemical + chemo agent or siRNA) to produce synergistic anticancer effects and overcome resistance ( Diagnostic/theranostic utility: Certain inorganic NPs (Au, Ag, quantum dots, magnetic NPs) provide strong imaging contrast (CT, optical, MRI) or photothermal/photodynamic capabilities enabling simultaneous detection and treatment (theranostics)

Wang, T., Wei, J
ResultsOvarian histoarchitecture is preserved by melatonin and glutatione against carboplatin-induced damage To evaluate the protective effects of Mel and GSH against CARB-induced ovarian damage, these two antioxidant agents were administered for one week prior to CARB treatment

PloS One (2012) 7(2):e30749

Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury