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Complement-mediated damage, along with subsequent proinflammatory and pro-fibrotic signaling, compromises the podocyte cytoskeleton and slit diaphragm, resulting in the loss of permselectivity and significant proteinuria

For example, noncanonical Notch pathway modulates mitochondrial function to promote cell survival by activation of mTORC2/AKT signaling with PINK1 (PTEN-induced kinase 1)

Glutamine plays a role in superoxide production and the expression of p47phox, p22phox and gp91phox in rat neutrophils

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Figure 8 Eleven samples were available for the immunoblot assay ( Figure 9 )