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DHA not only reduces GSH to GSSG but also inactivates GPX4 directly, facilitating LPO accumulation and cell ferroptosis collaboratively (Figure 5E)

In contrast, the expression levels of CYP11A1 and CYP17A1 in the LT1 and LT2 groups decreased in a dose-dependent manner, with the LT2 group displaying more significant inhibition

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10.1039/c7fo00341b [DOI] [PubMed] [Google Scholar] Mahajna J