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Further research revealed that YAP-related anti-ferroptotic activity was tied to the cardioprotective effects of PQQ, with YAP inhibition representing an effective means of partially reversing the cardioprotective and anti-ferroptotic effects of PQQ treatment

References: Regulation of glutathione synthesis
Two agonists on the same receptor amplify these without a matching efficacy gain

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Mutvei et al
(Springer International Publishing AG, Cham, Switzerland), 309329