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Low-density lipoprotein (LDL) cholesterol is a lipid compound susceptible to oxidation when allowed to build up on the walls of arteries to form atherosclerotic plaques

Antioxidants and ROS inhibitors aim to reduce oxidative damage by restoring redox balance

Glutathione restoration as indicator for cellular metabolism of astroglial cells

For successful NADs design, critical factors must be considered regarding sequence design, modification, and delivery, as well as the clinical translation, medical indication, and scale production feasibility

To regulate gene expression, Nrf2 will bind to the antioxidant response element (ARE) located in the promoter or enhancer region of target genes (Rushmore et al, 1991

A conformational change may occur upon binding, potentially activating intracellular signaling pathways primarily involving G-proteins