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Major reactive species, including ROS and reactive nitrogen species (RNS) consist of paramagnetic free radicals (superoxide O 2 - , hydroxyl HO , peroxy ROO , and nitric oxide free radical NO ) and diamagnetic molecules (hydrogen peroxide H 2 O 2 and peroxynitrite ONOO - ) which are products of the reactions of these free radicals

All animal procedures related to were approved by the Johns Hopkins University Animal Care and Use Committee

Dry mouth or restlessness rarely (reported in humans)

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