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Tchkonia T, Morbeck DE, Von Zglinicki T, et al

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Rats were assessed for fine motoric impairment with modified Irvine, Beatties and Bresnahan forelimb scale (IBB scale) that can detect recovery of both proximal and distal forelimb function including digit movements during a naturally occurring behavior that does not require extensive training or deprivation to enhance motivation (64)

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Regarding cuproptosis regulation, the key EMT transcription factor TWIST1 promotes glycolysis and cuproptosis by stabilizing hexokinase 2 (HK2) protein levels through the inhibition of its ubiquitination-mediated degradation [124]