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Over the past decade, peroxisome proliferator-activated receptor- coactivator-1 (PGC-1) has been demonstrated as a key transcriptional co-activator, providing a mechanistic insight into nuclear regulatory pathways in the biogenesis of mitochondria in skeletal muscle [7-9]

doi: 10.1016/j.freeradbiomed.2016.12.010, 5 ChengZ.RistowM

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As research progresses, the clinical implementation of these vascular promotion strategies will likely evolve, aiming to improve patient outcomes through more effective and targeted therapies that address the underlying mechanisms of vascular dysfunction in various diseases (75)