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Front Endocrinol (Lausanne) 13:1006376 Deepa Maheshvare M, Raha S, Knig M, Pal D

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In certain cancer cells, TP53 inhibits VKORC1L1 expression, which promotes ferroptosis and suppresses tumor growth [87]

Radiation therapy has been demonstrated to exert adverse effects on the cardiovascular system, thereby exacerbating the progression of cardiovascular disease, including atherosclerosis [148, 149]

Role of the Methionine Cycle in Epigenetics The role of methionine synthesis and regeneration, via the methionine cycle, in the methylation of DNA and histones, events that are central to epigenetic regulation of gene expression, is evident from the fact that this process is required for the synthesis of S-adenosylmethionine (SAM)