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Heres the kicker: when the body gets more than needed, it tries to excrete the excess

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In cultured cardiomyocytes, DOX concentrates in mitochondria, increasing mitochondrial iron deposition and ROS levels, and dexrazoxane has demonstrated efficacy in reversing DOX-induced cardiomyopathy by lowering mitochondrial iron levels

doi: 10.3889/oamjms.2015.111