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Anti-inflammatory, anti-oxidant and hepatoprotective effects of lactoferrin in rats

Several metabolic disturbances have been reported in aged experimental animals, including glucose intolerance, insulin resistance, impaired oxidative phosphorylation, reduced mitochondrial biosynthesis, and decreased fatty acid oxidation [154]

C.Smith-WarnerS

Gaussian graphical modeling has been used to reconstruct pathway reactions in metabolomics data 57

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Current therapeutic development encompasses multiple parallel approaches: novel pharmacological agents targeting thermogenic pathways, cell-based interventions to enhance brown adipose function, and genetic modifications designed to amplify thermogenic capacity in existing AT (430)