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SIRT-1 (threefold, 3.7-fold, 4.3-fold, 5.3-fold, and sixfold, respectively) (Fig

In addition, because kaempferol can act as a pro-oxidant, some studies have found that kaempferol has mutagenic and genotoxic effects [57]

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Ferroptosis is mainly characterized by the destruction of the mitochondria

This ring is not directly involved in the catalytic function of GSTs but forms hydrogen bonding interactions with the backbone amine group of the cysteine-residue of GSH and plays an important role in maintaining the protein in a catalytically active structure [28,29]

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