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MGO is predominantly formed by spontaneous degradation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P), which form during glycolysis [22, 25]

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In the decomposition reaction of H 2 O 2 or other organic peroxides (HOOR), two molecules of GSH reduce the substrate to H 2 O or the corresponding alcohol (HOR) and restore the enzyme forming GSSG with concomitant formation of GSSG and H 2 O