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*Correspondence: Yanhong Zhou, [email protected]

From these findings and the fact that glutathione is essential for lymphocyte proliferation and immune responses, , we hypothesized that abundant cystine/cysteine in the kidneys forms a unique metabolic microenvironment that supports ectopic lymphocyte proliferation, leading to the formation of TLS

In particular, we observed a further decrease of H 2 (Table S2)

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[117] suggest that Mg2+ deficiency and Ca increase cause an increase in the number of available substrates for radical oxidation