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These observations prompted testing of the efficacy of combining CDK4/6-inhibitors with antibodies that elicit immune-checkpoint blockade

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Specific alterations discussed potentiate differential responses to ICI due to upregulation of PD-L1 and other inhibitory ligands

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Hydrodynamic diameter and zeta potential of nanostructured lipid carriers: Emphasizing some parameters for correct measurements

Whether it is Free + Nano or Nano + Nano delivery, clinicians have to consider the sequence of drug delivery, balance the pharmacokinetics of the two drugs to reach the tumor site, and the time window between the two drugs, which increases the clinical workload