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Other proteins that bind KEAP1 and interfere with KEAP1-NRF2 interaction, promoting NRF2 accumulation and function in the nucleus, include: phosphoglycerate mutase 5 (PGAM5, a serine/threonine phosphatase related to the phosphoglycerate mutase family), which has been reported to be associated with mitochondria, so its interaction with KEAP1 may be regulated by mitochondrial signalling processes [187, 188]

Implementing prognostic and predictive biomarkers in CRC clinical trials

J Med Chem 54(10):36063623

Together, these features suggest that sequestration-based interactions mediated by GSTs may have been evolutionarily favored as a flexible and protective response to environmental chemical stress

Research has shown that A levels vary with sleep-wake cycles

(2024) developed a novel trastuzumab-functionalized liposomal system for co-delivery of pyrotinib, demonstrating improved antitumor activity in HER2-overexpressing breast cancer models