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Pharmacologically, modulating histone acetylation with LAC rapidly increased xCT and activated a network with mGlu2 receptors to prime enhanced glutamate homeostasis that promotes both pro-resilient and antidepressant-like responses (101)

10.3389/fgene.2019.00770 Front

Alata et al., 2015

A 12-month clinical trial demonstrated a significant reduction in VPT in patients treated with C-peptide compared with placebo

Categorical data were described using frequencies and percentages, and differences between groups were analyzed using the chi-square test or Fishers exact test