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Sterile alpha and toll-interleukin receptor-containing motif (SARM1) inhibitors Building on the therapeutic potential of modulating NAD + pathways, attention has also turned to SARM1, a pivotal enzyme in axon degeneration, functioning through its NAD + hydrolase activity

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39 A three-dose inhibition study demonstrated that yuanhuadine also reduced about 50% of the NNMT activity at 0.5 M in a biochemical assay