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Acknowledgements This work was supported by NIH grant R01 CA79882 to JMS from the National Cancer Institute and by a Predoctoral Fellowship in Pharmacology by Pharmaceutical Research and Manufacturers of America Foundation awarded to Austin M Dulak

If you experience severe side effects or any of these effects get worse, please notify your doctor promptly

Safety / Best Practices Standard laboratory safety practices must be followed when handling lyophilized powders and reconstituted solutions

Symptoms of B12 Deficiency Symptoms of B12 deficiency include: Skin with a yellowish undertone Sore and reddened tongue, and mouth ulcers Tingling in your extremities Fatigue, lethargy and apathy Alterations in walking gait and movement Vision problems Depression and irritability Behavioral changes Dark thoughts Poor memory and decision making Dry and brittle skin, hair and nails Infertility Benefits of B12 Injections and Infusions For many, eating more meat and animal products to boost Vitamin B12 is not an option, but your body cannot get by without at least baseline levels

All animals were hand gentled for 5 min per day during the 5-6 days of post-surgical recovery

DSIP breaks one side of this cycle by promoting deep restorative sleep, optimizing circadian rhythms, normalizing stress hormone patterns, and enhancing recovery processes during sleep