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To view a copy of this license, visit About this article Cite this article Bonifcio, V.D.B., Pereira, S.A., Serpa, J

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(8890), and is associated with tumor progression, invasion, and metastasis (91)

BID dose may be improved by about 30-fold upon extending the rat half-life from 0.5 to 2 h (4-fold improvement in half-life) even if the unbound clearance remained the same (about 7-fold improvement when half-life changes from 0.5 to 1 h and about 2-fold improvement when rat half-life changes from 1 to 1.5 h)

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