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The absence of pathognomonic imaging patterns, limited prospective studies, and a need for standardized criteria underscore the challenges in accurately diagnosing and understanding lipedema, necessitating more robust research approaches

Direct reproductive tissue effects remain theoretically possible but unproven in clinical contexts

Among the inhibitors of GCL, l-buthionine sulfoximine (BSO) is the most potent and has already been in the clinical trial stage [11, 12]

doi: 10.1006/bbrc.1997.7703

Age, sex, BMI, diabetes status, genetic markers, microbiome composition, and lifestyle factors all influence outcomes

Many of the symptoms overlap with those in ME/CFS, similarly there is no diagnostic test