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The FDAs decision was supported by data from the Phase II ROSEWOOD trial, in which the BrukinsaGazyva combo led to a 69% overall response rate (ORR) compared to 46% ORR in patients treated with Gazyva alone, according to BeiGene

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However, in many cases these protocols fail to achieve efficient removal of all DSA and long-term outcomes of patients with persistent DSA are far worse when compared to non-sensitized patients

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Alternative Medicine Review, 13(1), 75-76

United States Pharmacopeia
