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TABLE 7 Summary of clinical trials investigating curcumin formulations in different types of cancer

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In this context, combining targeted ammonia metabolism intervention (e.g., using the GLS1 inhibitor CB-839) with CAR-T cell infusion not only blocks tumor cell utilization of ammonia but also enhances T cell adaptability through metabolic plasticity, thereby simultaneously alleviating the immunosuppressive microenvironment and prolonging CAR-T cell persistence (156, 159)

1,1518 This deficient understanding is likely due to the structural diversity of aldehyde derivatives and their correspondingly different biological targets and chemical reactions